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Many IV antiepileptic drugs administered in emergency situations to patients with prolonged seizures have serious adverse effects. For this reason, the authors conducted a multicenter, open-label, prospective, dose-escalation study of IV valproate sodium administered to patients with epilepsy at rates of infusion of up to 6 mg/kg/minute and doses of up to 30 mg/kg. Valproate sodium had no clinically significant negative effects on blood pressure and pulse rate and caused only mild-to-moderate, reversible adverse events. |
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adverse drug reaction
anticonvulsants,loading dose
anticonvulsants,parenteral administration
anticonvulsants,rate of administration
anticonvulsants,untoward effects of
seizure
seizure,treatment of
sodium valproate
sodium valproate,intravenous
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